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KMID : 0191120220370410297
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Journal of Korean Medical Science
2022 Volume.37 No. 41 p.297 ~ p.297
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Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea
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Chung You-Seung
Kim Eun-Jin
Kim Hee-Sung
Park Kyung-Hwa
Baek Ji-Hyeon
Kim Jung-Ok
Lee Ji-Yeon
Lee Chang-Seop
Lim Seung-Jin
Kim Shin-Woo
Kim Eu-Suk
Shi Hye-Jin
Hong Shin-Hee
Jun Jae-Bum
Hong Kyung-Wook
Choi Jae-Phil
Kim Jin-Yeong
Yang Kyung-Sook
Yoon Young-Kyung
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Abstract
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Background: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19.
Methods: This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021.
Results: A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04?1.15) and parity (OR, 1.703, 95% CI, 1.13?2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns’ amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2.
Conclusion: At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis.
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KEYWORD
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Severe Acute Respiratory Syndrome Coronavirus 2, Coronavirus Disease 2019, Pregnancy, Neonate
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